General Information of Drug (ID: DM4BDON)

Drug Name
Methylprednisolone
Synonyms Depo-medrol; M-predrol; Medrol; Medrol Acetate
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Approved [1]
Spinal cord injury ND51.2 Investigative [2]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 374.5
Topological Polar Surface Area (xlogp) 1.9
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 5
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [3]
Bioavailability
82% of drug becomes completely available to its intended biological destination(s) [4]
Clearance
The drug present in the plasma can be removed from the body at the rate of 6.1 mL/min/kg [5]
Elimination
4.9% of drug is excreted from urine in the unchanged form [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 2.3 hours [5]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 11.1354 micromolar/kg/day [6]
Unbound Fraction
The unbound fraction of drug in plasma is 0.23% [5]
Vd
Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 1.2 L/kg [5]
Water Solubility
The ability of drug to dissolve in water is measured as 0.3236 mg/mL [3]
Chemical Identifiers
Formula
C22H30O5
IUPAC Name
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Canonical SMILES
C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O
InChI
InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
InChIKey
VHRSUDSXCMQTMA-PJHHCJLFSA-N
Cross-matching ID
PubChem CID
6741
ChEBI ID
CHEBI:6888
CAS Number
83-43-2
DrugBank ID
DB00959
TTD ID
D08PIQ
VARIDT ID
DR00128
INTEDE ID
DR1056
ACDINA ID
D00420

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glucocorticoid receptor (NR3C1) TTYRL6O GCR_HUMAN Modulator [7]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [8]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME
DE4LYSA CP3A4_HUMAN Substrate [9]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
P-glycoprotein 1 (ABCB1) DTP P-GP 7.23E-01 -8.20E-02 -3.22E-01
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 9.85E-01 2.24E-02 7.33E-02
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Methylprednisolone
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Larotrectinib DM26CQR Moderate Decreased metabolism of Methylprednisolone caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [32]
Armodafinil DMGB035 Minor Increased metabolism of Methylprednisolone caused by Armodafinil mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [33]
LEE011 DMMX75K Moderate Decreased metabolism of Methylprednisolone caused by LEE011 mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [34]
Coadministration of a Drug Treating the Disease Different from Methylprednisolone (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Sodium bicarbonate DMMU6BJ Minor Decreased absorption of Methylprednisolone due to altered gastric pH caused by Sodium bicarbonate. Acidosis [5C73] [35]
Posaconazole DMUL5EW Major Decreased metabolism of Methylprednisolone caused by Posaconazole mediated inhibition of CYP450 enzyme. Aspergillosis [1F20] [36]
Levalbuterol DM5YBO1 Minor Increased risk of hypokalemia by the combination of Methylprednisolone and Levalbuterol. Asthma [CA23] [32]
Pirbuterol DMI5678 Minor Increased risk of hypokalemia by the combination of Methylprednisolone and Pirbuterol. Asthma [CA23] [36]
Salbutamol DMN9CWF Minor Increased risk of hypokalemia by the combination of Methylprednisolone and Salbutamol. Asthma [CA23] [32]
Roflumilast DMPGHY8 Moderate Additive immunosuppressive effects by the combination of Methylprednisolone and Roflumilast. Asthma [CA23] [37]
Formoterol DMSOURV Minor Increased risk of hypokalemia by the combination of Methylprednisolone and Formoterol. Asthma [CA23] [36]
Ofloxacin DM0VQN3 Major Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Ofloxacin. Bacterial infection [1A00-1C4Z] [38]
Dalfopristin DM4LTKV Moderate Decreased metabolism of Methylprednisolone caused by Dalfopristin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [39]
Clarithromycin DM4M1SG Major Decreased metabolism of Methylprednisolone caused by Clarithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [36]
Sparfloxacin DMB4HCT Major Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Sparfloxacin. Bacterial infection [1A00-1C4Z] [38]
Gemifloxacin DMHT34O Major Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Gemifloxacin. Bacterial infection [1A00-1C4Z] [38]
Norfloxacin DMIZ6W2 Major Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Norfloxacin. Bacterial infection [1A00-1C4Z] [38]
ABT-492 DMJFD2I Major Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and ABT-492. Bacterial infection [1A00-1C4Z] [38]
Levofloxacin DMS60RB Major Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Levofloxacin. Bacterial infection [1A00-1C4Z] [38]
Troleandomycin DMUZNIG Major Decreased metabolism of Methylprednisolone caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [36]
Lomefloxacin DMVRH9C Major Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Lomefloxacin. Bacterial infection [1A00-1C4Z] [38]
Telithromycin DMZ4P3A Major Decreased metabolism of Methylprednisolone caused by Telithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [36]
Lapatinib DM3BH1Y Moderate Decreased metabolism of Methylprednisolone caused by Lapatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [40]
Tucatinib DMBESUA Major Decreased metabolism of Methylprednisolone caused by Tucatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [36]
Vilanterol DMF5EK1 Minor Increased risk of hypokalemia by the combination of Methylprednisolone and Vilanterol. Chronic obstructive pulmonary disease [CA22] [32]
Indacaterol DMQJHR7 Minor Increased risk of hypokalemia by the combination of Methylprednisolone and Indacaterol. Chronic obstructive pulmonary disease [CA22] [36]
Arformoterol DMYM974 Minor Increased risk of hypokalemia by the combination of Methylprednisolone and Arformoterol. Chronic obstructive pulmonary disease [CA22] [36]
Ketoprofen DMRKXPT Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Methylprednisolone and Ketoprofen. Chronic pain [MG30] [41]
Isoproterenol DMK7MEY Minor Increased risk of hypokalemia by the combination of Methylprednisolone and Isoproterenol. Conduction disorder [BC63] [32]
Pancuronium DMB0VY8 Moderate Additive neuromuscular blocking effects by the combination of Methylprednisolone and Pancuronium. Corneal disease [9A76-9A78] [36]
Tubocurarine DMBZIVP Moderate Additive neuromuscular blocking effects by the combination of Methylprednisolone and Tubocurarine. Corneal disease [9A76-9A78] [36]
Ivacaftor DMZC1HS Moderate Decreased clearance of Methylprednisolone due to the transporter inhibition by Ivacaftor. Cystic fibrosis [CA25] [42]
MK-8228 DMOB58Q Moderate Decreased metabolism of Methylprednisolone caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [43]
Nefazodone DM4ZS8M Major Decreased metabolism of Methylprednisolone caused by Nefazodone mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [36]
Stiripentol DMMSDOY Moderate Decreased metabolism of Methylprednisolone caused by Stiripentol mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [44]
Fosphenytoin DMOX3LB Moderate Increased metabolism of Methylprednisolone caused by Fosphenytoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [45]
Phenobarbital DMXZOCG Moderate Increased metabolism of Methylprednisolone caused by Phenobarbital mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [46]
Tazemetostat DMWP1BH Moderate Increased metabolism of Methylprednisolone caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [47]
Itraconazole DMCR1MV Major Decreased metabolism of Methylprednisolone caused by Itraconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [36]
Ketoconazole DMPZI3Q Major Decreased metabolism of Methylprednisolone caused by Ketoconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [36]
Boceprevir DMBSHMF Major Decreased metabolism of Methylprednisolone caused by Boceprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [36]
Telaprevir DMMRV29 Major Decreased metabolism of Methylprednisolone caused by Telaprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [36]
Rifampin DMA8J1G Moderate Increased metabolism of Methylprednisolone caused by Rifampin mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [48]
Rifapentine DMCHV4I Moderate Increased metabolism of Methylprednisolone caused by Rifapentine mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [49]
Fosamprenavir DM4W9B3 Major Decreased metabolism of Methylprednisolone caused by Fosamprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [36]
Cobicistat DM6L4H2 Major Decreased metabolism of Methylprednisolone caused by Cobicistat mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [36]
Saquinavir DMG814N Major Decreased metabolism of Methylprednisolone caused by Saquinavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [36]
Darunavir DMN3GCH Moderate Decreased metabolism of Methylprednisolone caused by Darunavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [36]
Atazanavir DMSYRBX Major Decreased metabolism of Methylprednisolone caused by Atazanavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [36]
Bempedoic acid DM1CI9R Major Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Bempedoic acid. Hyper-lipoproteinaemia [5C80] [50]
Teriflunomide DMQ2FKJ Major Additive immunosuppressive effects by the combination of Methylprednisolone and Teriflunomide. Hyper-lipoproteinaemia [5C80] [51]
Berotralstat DMWA2DZ Moderate Decreased metabolism of Methylprednisolone caused by Berotralstat mediated inhibition of CYP450 enzyme. Innate/adaptive immunodeficiency [4A00] [52]
Amobarbital DM0GQ8N Moderate Increased metabolism of Methylprednisolone caused by Amobarbital mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [46]
Denosumab DMNI0KO Moderate Additive immunosuppressive effects by the combination of Methylprednisolone and Denosumab. Low bone mass disorder [FB83] [53]
PF-06463922 DMKM7EW Moderate Increased metabolism of Methylprednisolone caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [54]
Selpercatinib DMZR15V Moderate Decreased metabolism of Methylprednisolone caused by Selpercatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [37]
Idelalisib DM602WT Major Decreased metabolism of Methylprednisolone caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [36]
IPI-145 DMWA24P Moderate Decreased metabolism of Methylprednisolone caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [55]
Nivolumab DMAB9QE Moderate Additive immunosuppressive effects by the combination of Methylprednisolone and Nivolumab. Melanoma [2C30] [36]
Pembrolizumab DMFQEA6 Moderate Additive immunosuppressive effects by the combination of Methylprednisolone and Pembrolizumab. Melanoma [2C30] [36]
Ipilimumab DMJTIYK Moderate Additive immunosuppressive effects by the combination of Methylprednisolone and Ipilimumab. Melanoma [2C30] [36]
Cemiplimab DMKMJHE Moderate Additive immunosuppressive effects by the combination of Methylprednisolone and Cemiplimab. Melanoma [2C30] [36]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Methylprednisolone caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [37]
Thalidomide DM70BU5 Major Additive thrombogenic effects by the combination of Methylprednisolone and Thalidomide. Multiple myeloma [2A83] [56]
Tecfidera DM2OVDT Moderate Additive immunosuppressive effects by the combination of Methylprednisolone and Tecfidera. Multiple sclerosis [8A40] [57]
Siponimod DM2R86O Major Additive immunosuppressive effects by the combination of Methylprednisolone and Siponimod. Multiple sclerosis [8A40] [32]
Fingolimod DM5JVAN Major Additive immunosuppressive effects by the combination of Methylprednisolone and Fingolimod. Multiple sclerosis [8A40] [58]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Methylprednisolone and Ocrelizumab. Multiple sclerosis [8A40] [59]
Ozanimod DMT6AM2 Major Additive immunosuppressive effects by the combination of Methylprednisolone and Ozanimod. Multiple sclerosis [8A40] [37]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Methylprednisolone caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [36]
Omacetaxine mepesuccinate DMPU2WX Moderate Additive immunosuppressive effects by the combination of Methylprednisolone and Omacetaxine mepesuccinate. Myeloproliferative neoplasm [2A20] [60]
Bupropion DM5PCS7 Major Increased risk of lowers seizure threshold by the combination of Methylprednisolone and Bupropion. Nicotine use disorder [6C4A] [61]
Atezolizumab DMMF8U0 Moderate Additive immunosuppressive effects by the combination of Methylprednisolone and Atezolizumab. Non-small cell lung cancer [2C25] [36]
Rucaparib DM9PVX8 Moderate Decreased metabolism of Methylprednisolone caused by Rucaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [62]
Ibuprofen DM8VCBE Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Methylprednisolone and Ibuprofen. Pain [MG30-MG3Z] [41]
Abametapir DM2RX0I Moderate Decreased metabolism of Methylprednisolone caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [63]
Lefamulin DME6G97 Moderate Decreased metabolism of Methylprednisolone caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [64]
Choline salicylate DM8P137 Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Methylprednisolone and Choline salicylate. Postoperative inflammation [1A00-CA43] [65]
Bromfenac DMKB79O Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Methylprednisolone and Bromfenac. Postoperative inflammation [1A00-CA43] [41]
Lonafarnib DMGM2Z6 Major Decreased metabolism of Methylprednisolone caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [36]
Temsirolimus DMS104F Moderate Increased plasma concentrations of Methylprednisolone and Temsirolimus due to competitive inhibition of the same metabolic pathway. Renal cell carcinoma [2C90] [66]
Gatifloxacin DMSL679 Major Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Gatifloxacin. Respiratory infection [CA07-CA4Z] [38]
Salsalate DM13P4C Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Methylprednisolone and Salsalate. Rheumatoid arthritis [FA20] [65]
Canakinumab DM8HLO5 Moderate Additive immunosuppressive effects by the combination of Methylprednisolone and Canakinumab. Rheumatoid arthritis [FA20] [67]
Oxaprozin DM9UB0P Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Methylprednisolone and Oxaprozin. Rheumatoid arthritis [FA20] [41]
Rilonacept DMGLUQS Moderate Additive immunosuppressive effects by the combination of Methylprednisolone and Rilonacept. Rheumatoid arthritis [FA20] [67]
Golimumab DMHZV7X Major Additive immunosuppressive effects by the combination of Methylprednisolone and Golimumab. Rheumatoid arthritis [FA20] [68]
Leflunomide DMR8ONJ Major Additive immunosuppressive effects by the combination of Methylprednisolone and Leflunomide. Rheumatoid arthritis [FA20] [51]
Anthrax vaccine DM9GSWY Moderate Antagonize the effect of Methylprednisolone when combined with Anthrax vaccine. Sepsis [1G40-1G41] [69]
Voxelotor DMCS6M5 Moderate Decreased metabolism of Methylprednisolone caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [36]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Methylprednisolone caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [37]
Pitolisant DM8RFNJ Moderate Increased risk of GI mucosal injury/bleeding risk by the combination of Methylprednisolone and Pitolisant. Somnolence [MG42] [37]
Fostamatinib DM6AUHV Moderate Decreased metabolism of Methylprednisolone caused by Fostamatinib mediated inhibition of CYP450 enzyme. Thrombocytopenia [3B64] [70]
Doxacurium DMKE7L9 Moderate Additive neuromuscular blocking effects by the combination of Methylprednisolone and Doxacurium. Tonus and reflex abnormality [MB47] [36]
Vecuronium DMP0UK2 Moderate Additive neuromuscular blocking effects by the combination of Methylprednisolone and Vecuronium. Tonus and reflex abnormality [MB47] [36]
Durvalumab DM4PVDY Moderate Additive immunosuppressive effects by the combination of Methylprednisolone and Durvalumab. Ureteral cancer [2C92] [36]
⏷ Show the Full List of 92 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Stearic acid E00079 5281 Emulsifying agent; Solubilizing agent; Viscosity-controlling agent; lubricant
Sunset yellow FCF E00255 17730 Colorant
Beta-D-lactose E00099 6134 Diluent; Dry powder inhaler carrier; Lyophilization aid
Calcium stearate E00244 15324 lubricant
Carmellose sodium E00625 Not Available Disintegrant
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Saccharose E00091 5988 Binding agent; Coating agent; Cryoprotectant; Diluent; Flavoring agent; Suspending agent; Viscosity-controlling agent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sorbic acid E00441 643460 Antimicrobial preservative
⏷ Show the Full List of 11 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Methylprednisolone 4 mg tablet 4 mg Oral Tablet Oral
Methylprednisolone 2 mg tablet 2 mg Oral Tablet Oral
Methylprednisolone 16 mg tablet 16 mg Oral Tablet Oral
Methylprednisolone 32 mg tablet 32 mg Oral Tablet Oral
Methylprednisolone 8 mg tablet 8 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

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42 Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
43 Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
44 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
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47 Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
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49 Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
50 Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
51 Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
52 Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
53 Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
54 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
55 Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
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57 Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
58 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
59 Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
60 Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
61 Product Information. Wellbutrin XL (buPROPion). GlaxoSmithKline, Philadelphia, PA.
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63 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
64 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
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66 Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
67 Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
68 Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
69 CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
70 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.